APPLICATIONS
CryLaS laser systems are used extensively in many applications within several markets including, but not limited to, scientific research, medical/biomedical, semiconductor and industrial. Our compact, low noise lasers have excellent long-term stability, making them ideal for demanding 24/7 and volume applications. The menu below is a cross-section representation of applications in today’s markets.
Questions regarding products for applications not listed here should be directed to sales@crylas.de.
APPLICATION NOTES
Ablation
Laser ablation is a removal process of material from surfaces of an object by vaporization, chipping or other erosive processes. Examples of laser ablation are described below as for biological tissues in medicine, biology and for silicon.
Related products: DSS1064-Q, DSS1064-450, DSS1064-3000, FDSS532-Q, FDSS532-150, FTSS355-Q, FTSS355-50, FQSS266-200
Related articles:
2. Protein crystals IR laser ablated from aqueous solution at high speed retain their diffractive properties: applications in high-speed serial crystallography, 2017
3. On the Roles of Actin Stress Fibers on the Mechanical Regulation of Nucleus in Adherent Cells, 2014
4. Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C. elegans, 2011
Raman Spectroscopy
UV Raman spectroscopy with excitation wavelengths below 270 nm is a very promising technique for obtaining fluorescence-free Raman spectra, since fluorescence usually can be found only at wavelengths longer than 300 nm.
Related products: FQCW266-10, FQCW266-25, FQCW266-50, FQCW266-10-C
Related articles:
1. Molecular recognition of carboxylates in the protein leucine [...]: residue-specific, sensitive and label-free probing by UV resonance Raman spectroscopy, 2018
2. UV Raman Spectroscopy article of DTU, 2016
4. Determination of sp³ fraction in ta-C coating using XPS and Raman spectroscopy, 2016
5. Investigation of L(+)-Ascorbic acid with Raman spectroscopy in visible and UV light, 2014
Fluorescence
Laser-induced fluorescence (LIF) is a spectroscopic method in which an atom or molecule is excited to a higher energy level by the absorption of laser photons followed by spontaneous emission of photons. LIF is used for studying structure of molecules, detection of selective species and flow visualization measurements.
Fluorescence lifetime imaging microscopy (FLIM) is an imaging technique for producing an image based on the differences in the exponential decay rate of the fluorescence from a fluorescent sample. It can be used as an imaging technique in confocal microscopy, two-photon excitation microscopy, and multiphoton tomography. The lifetime of the fluorophore signal, rather than its intensity, is used to create the image in FLIM. This has the advantage of minimizing the effect of photon scattering in thick layers of sample.
Related products: FQSS266-Q, FQSS266-50, FQCW266-10-C, FTSS355-Q, FDSS532-Q
Related articles:
5. Analysis of gas-phase polycyclic aromatic hydrocarbon mixtures by laser-induced fluorescence, 2010
Photoluminescence
Photoluminescence (PL) is light emission from any form of matter after the absorption of photons. It is one of many forms of luminescence. Following excitation various relaxation processes typically occur in which other photons are re-radiated. Time periods between absorption and emission may vary: ranging from short femtosecond regime for emission involving free-carrier plasma in inorganic semiconductors up to milliseconds for phosphorescence processes in molecular systems and under special circumstances delay of emission may even span from minutes up to hours. Observation of PL at a certain energy can be viewed as an indication that an electron populated an excited state associated with this transition energy and act as sources for PL in many-body systems such as semiconductors.
Related products: FQSS266-Q, FQCW266-10, FQCW266-25, FQCW266-50, FQCW266-10-C, FTSS355-50, FDSS355-Q, FDSS532-Q
Related articles:
3. Process control of MOCVD growth for LEDs by in-situ photoluminescence, 2016
5. Transport of dipolar excitons in (Al,Ga)N/GaN quantum wells, 2015
7. Luminescence of Eu ion in alumina prepared by plasma electrolytic oxidation, 2015
8. Analysis of cadmium-based pigments with time-resolved photoluminescence, 2014
9. Extended-Defect-Related Photoluminescence Line at 3.33 eV in Nanostructured ZnO Thin Films, 2013
10. Photoluminescence from SiNxOy films deposited by reactive sputtering, 2013
12. The luminescence of ZnO ceramics, 2010
Mass Spectrometry
Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio. In simpler terms, a mass spectrum measures the masses within a sample. Mass spectrometry is used in many different fields, as in pharmacology and for protein characterisation, and is applied to pure samples as well as complex mixtures. Laser assisted creation for ions was dominated by excimer laser many decades and DPSSL show benefits for replacement.
Related products: FQSS213-Q, FQSS213-50, eMOPA213-20, FQSS266-50, FQSS266-200, FTSS355-Q
Related articles:
1. Methods of Ultraviolet Photodissociation for Mass Spectrometry, 2018
2. Directed-Backbone Dissociation Following Bond-Specific Carbon-Sulfur UVPD at 213 nm, 2018
3. MALDI MS Imaging at Acquisition Rates Exceeding 100 Pixels per Second, 2018
5. The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics, 2017
Microdissection
Laser-capture microdissection (LCM) is a method to procure subpopulations of tissue cells under direct microscopic visualization. LCM technology can harvest the cells of interest directly or can isolate specific cells by cutting away unwanted cells to give histologically pure enriched cell populations. A variety of downstream applications exist: DNA genotyping and loss-of-heterozygosity (LOH) analysis, RNA transcript profiling, cDNA library generation, proteomics discovery and signal-pathway profiling.
Related products: FTSS355-50, FTSS355-Q
Related articles:
1. Auxin analysis using laser microdissected plant tissues sections, 2018
9. Analysis of gas-phase polycyclic aromatic hydrocarbon mixtures by laser-induced fluorescence, 2010
Lithography
Photolithography, also known as UV lithography (UVL), is a process used in microfabrication to pattern parts of a thin film or the bulk of a substrate. It uses photons to transfer a geometric pattern from a photomask to a light-sensitive chemical photoresist on the substrate. For example, complex integrated circuits or CMOS wafer go through several photolithographic cycles. Other techniques as laser interference lithography (LIL), nano-imprint lithography (NIL) and stereolithography (SLA) are techniques for patterning regular arrays of fine features, without the use of complex optical photomasks and 3D prototyping for medical and biotechnology applications.
Related products: FQCW266-50, FQCW266-100, FQCW266-200, FQCW266-500, FTSS355-Q, FTSS355-50
Related articles:
2. Optimized vascular network by stereolithography for tissue engineered skin, 2018
Scatterometry
Scatterometers are widely used in metrology for roughness of polished and lapped surfaces in semiconductor and precision machining industries. They provide a fast and non-contact alternative to traditional stylus methods for topography assessment. Scatterometers are compatible with vacuum environment, are not sensitive to vibration, and can be readily integrated with surface processing and other metrology tools.
Related products: FQCW266-10, FQCW266-25, FQCW266-50, FQCW266-10-C
Related articles:
1. Metrology of nanoscale grating structures by UV scatterometry, 2017
3. First steps towards a scatterometry reference standard, 2012
Engraving / Marking
Laser engraving, which is a subset of laser marking, is the practice of using laser to engrave an object. Laser marking, on the other hand, is a broader category of methods to leave marks on an object, which also includes color change due to chemical/molecular alteration, charring, foaming, melting, ablation, and more. Transparent materials as glass, polymers and gemstones can be marked with UV laser sources.
Related products: eMOPA266-40, eMOPA213-20, MOPA355-200, MOPA355-500mW, FQSS266-Q, FQSS213-Q
Related articles:
2. System and method for gemstone microinscription, 2006
3. Laser making system and certificate for a gemstone, 1996