CryLaS laser systems are used extensively in many applications within several markets including, but not limited to, scientific research, medical/biomedical, semiconductor and industrial. Our compact, low noise lasers have excellent long-term stability, making them ideal for demanding 24/7 and volume applications. The menu below is a cross-section representation of applications in today's markets.
Questions regarding products for applications not listed here should be directed to firstname.lastname@example.org.
Laser ablation is a removal process of material from surfaces of an object by vaporization, chipping or other erosive processes. Examples of laser ablation are described below as for biological tissues in medicine, biology and for silicon.
2. Protein crystals IR laser ablated from aqueous solution at high speed retain their diffractive properties: applications in high-speed serial crystallography, 2017
3. On the Roles of Actin Stress Fibers on the Mechanical Regulation of Nucleus in Adherent Cells, 2014
UV Raman spectroscopy with excitation wavelengths below 270 nm is a very promising technique for obtaining fluorescence-free Raman spectra, since fluorescence usually can be found only at wavelengths longer than 300 nm.
1. Molecular recognition of carboxylates in the protein leucine [...]: residue-specific, sensitive and label-free probing by UV resonance Raman spectroscopy, 2018
2. UV Raman Spectroscopy article of DTU, 2016
Laser-induced fluorescence (LIF) is a spectroscopic method in which an atom or molecule is excited to a higher energy level by the absorption of laser photons followed by spontaneous emission of photons. LIF is used for studying structure of molecules, detection of selective species and flow visualization measurements.
Fluorescence lifetime imaging microscopy (FLIM) is an imaging technique for producing an image based on the differences in the exponential decay rate of the fluorescence from a fluorescent sample. It can be used as an imaging technique in confocal microscopy, two-photon excitation microscopy, and multiphoton tomography. The lifetime of the fluorophore signal, rather than its intensity, is used to create the image in FLIM. This has the advantage of minimizing the effect of photon scattering in thick layers of sample.
Photoluminescence (PL) is light emission from any form of matter after the absorption of photons. It is one of many forms of luminescence. Following excitation various relaxation processes typically occur in which other photons are re-radiated. Time periods between absorption and emission may vary: ranging from short femtosecond regime for emission involving free-carrier plasma in inorganic semiconductors up to milliseconds for phosphorescence processes in molecular systems and under special circumstances delay of emission may even span from minutes up to hours. Observation of PL at a certain energy can be viewed as an indication that an electron populated an excited state associated with this transition energy and act as sources for PL in many-body systems such as semiconductors.
Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio. In simpler terms, a mass spectrum measures the masses within a sample. Mass spectrometry is used in many different fields, as in pharmacology and for protein characterisation, and is applied to pure samples as well as complex mixtures. Laser assisted creation for ions was dominated by excimer laser many decades and DPSSL show benefits for replacement.
Laser-capture microdissection (LCM) is a method to procure subpopulations of tissue cells under direct microscopic visualization. LCM technology can harvest the cells of interest directly or can isolate specific cells by cutting away unwanted cells to give histologically pure enriched cell populations. A variety of downstream applications exist: DNA genotyping and loss-of-heterozygosity (LOH) analysis, RNA transcript profiling, cDNA library generation, proteomics discovery and signal-pathway profiling.
Photolithography, also known as UV lithography (UVL), is a process used in microfabrication to pattern parts of a thin film or the bulk of a substrate. It uses photons to transfer a geometric pattern from a photomask to a light-sensitive chemical photoresist on the substrate. For example, complex integrated circuits or CMOS wafer go through several photolithographic cycles. Other techniques as laser interference lithography (LIL), nano-imprint lithography (NIL) and stereolithography (SLA) are techniques for patterning regular arrays of fine features, without the use of complex optical photomasks and 3D prototyping for medical and biotechnology applications.
Scatterometers are widely used in metrology for roughness of polished and lapped surfaces in semiconductor and precision machining industries. They provide a fast and non-contact alternative to traditional stylus methods for topography assessment. Scatterometers are compatible with vacuum environment, are not sensitive to vibration, and can be readily integrated with surface processing and other metrology tools.
Engraving / Marking
Laser engraving, which is a subset of laser marking, is the practice of using laser to engrave an object. Laser marking, on the other hand, is a broader category of methods to leave marks on an object, which also includes color change due to chemical/molecular alteration, charring, foaming, melting, ablation, and more. Transparent materials as glass, polymers and gemstones can be marked with UV laser sources.